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Compound InformationSONAR Target prediction
Name:

AMCINONIDE

Unique Identifier:SPE01503816
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:467.294 g/mol
X log p:4.288  (online calculus)
Lipinksi Failures0
TPSA78.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:7
Rotatable Bond Count:4
Canonical Smiles:CC(=O)OCC(=O)C12OC3(CCCC3)OC1CC1C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C
Source:synthetic
Therapeutics:glucocorticoid, antiinflammatory
Generic_name:Amcinonide
Drug_type:Approved Drug
Pharmgkb_id:PA448364
Kegg_compound_id:D01387
Drugbank_id:APRD00788
Logp:3.269
Cas_registry_number:51022-69-6
Drug_category:Corticosteroids, topical; ATC:D07AC11
Indication:For the relief of the inflammatory and pruritic manifestations of
corticosteroid-responsive dermatoses.
Pharmacology:Amcinonide is a topical corticosteroid. The topical corticosteroids constitute a
class of primarily synthetic steroids used as anti-inflammatory and antipruritic
agents. Amcinonide reduces or inhibits the actions of chemicals in the body that
cause inflammation, redness, and swelling. The mechanism of anti-inflammatory
activity of the topical corticosteroids is unclear. Various laboratory methods,
including vasoconstrictor assays, are used to compare and predict potencies and/or
clinical efficacies of the topical corticosteroids. There is some evidence to
suggest that a recognizable correlation exists between vasoconstrictor potency and
therapeutic efficacy in man. When in an ointment form, amcinonide also helps the
skin maintain moisture.
Mechanism_of_action:The mechanism of the anti-inflammatory activity of the topical steroids, in general,
is unclear. However, corticosteroids are thought to act by the induction of
phospholipase A2 inhibitory proteins, collectively called lipocortins. It is
postulated that these proteins control the biosynthesis of potent mediators of
inflammation such as prostaglandins and leukotrienes by inhibiting the release of
their common precursor, arachidonic acid. Arachidonic acid is released from membrane
phospholipids by phospholipase A2. Amcinonide has affinity for the glucocorticoid
receptor. It has weak affinity for the progesterone receptor, and virtually no
affinity for the mineralocorticoid, estrogen, or androgen receptors.
Organisms_affected:Humans and other mammals

Found: 205 nonactive as graph: single | with analogs [1] << Back 101 102 103 104 105 106 107 108 109 110  Next >> [205]
Species: 4932
Condition: BCK2
Replicates: 2
Raw OD Value: r im 0.7744±0.0059397
Normalized OD Score: sc h 1.0182±0.00731004
Z-Score: 0.7529±0.213883
p-Value: 0.456632
Z-Factor: -4.80489
Fitness Defect: 0.7839
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Spectrum
Plate Number and Position:17|F6
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:26.40 Celcius
Date:2006-03-29 YYYY-MM-DD
Plate CH Control (+):0.037925±0.00177
Plate DMSO Control (-):0.7215±0.02863
Plate Z-Factor:0.8042
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DBLink | Rows returned: 4
2133
39858
443958
5702266

internal high similarity DBLink | Rows returned: 2
SPE01500587 0.9194
SPE01500303 0.9385

active | Cluster 1865 | Additional Members: 13 | Rows returned: 3
Prest990 0.494845360824742
SPE01500136 0.494845360824742
SPE01503210 0.355555555555556

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