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Compound InformationSONAR Target prediction
Name:

FOSCARNET SODIUM

Unique Identifier:SPE01502019
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:191.951 g/mol
X log p:-2.608  (online calculus)
Lipinksi Failures0
TPSA113.13
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:5
Rotatable Bond Count:1
Canonical Smiles:[Na+].[Na+].[Na+].[O-]C(=O)P([O-])([O-])=O
Source:synthetic
Therapeutics:antiviral
Generic_name:Foscarnet
Chemical_iupac_name:phosphonomethanoic acid
Drug_type:Approved Drug
Pharmgkb_id:PA449706
Kegg_compound_id:C07623
Drugbank_id:APRD00669
Melting_point:88.06 oC
H2o_solubility:Complete
Cas_registry_number:63585-09-1
Drug_category:Antivirals; Reverse Transcriptase Inhibitors; ATC:J05AD01
Indication:For the treatment of CMV retinitis in patients with acquired immunodeficiency
syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV
infections in immunocompromised patients.
Pharmacology:Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits
replication of herpes viruses in vitro including cytomegalovirus (CMV) and
herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require
activation (phosphorylation) by thymidine kinase or other kinases and therefore is
active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV
strains resistant to acyclovir or CMV strains resistant to ganciclovir may be
sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with
alterations in the viral DNA polymerase may be resistant to foscarnet and may not
respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has
been shown to have enhanced activity in vitro.
Mechanism_of_action:Foscarnet exerts its antiviral activity by a selective inhibition at the
pyrophosphate binding site on virus-specific DNA polymerases at concentrations that
do not affect cellular DNA polymerases.
Organisms_affected:Human herpes viruses

Found: 8 active | as graph: single | with analogs << Back 1 2 3 4 5 6 7 8 Next >> 
Species: 4932
Condition: BCK1
Replicates: 2
Raw OD Value: r im 0.9205±0.00848528
Normalized OD Score: sc h 0.7385±0.0127424
Z-Score: -5.1137±0.339441
p-Value: 0.000000590626
Z-Factor: 0.444552
Fitness Defect: 14.3421
Bioactivity Statement: Active
Experimental Conditions
Library:Spectrum_ED
Plate Number and Position:6|G10
Drug Concentration:50.00 nM
OD Absorbance:595 nm
Robot Temperature:30.00 Celcius
Date:2010-08-10 YYYY-MM-DD
Plate CH Control (+):0.08725±0.00370
Plate DMSO Control (-):0.9445±0.02697
Plate Z-Factor:0.8822
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DBLink | Rows returned: 112 Next >> 
3414 phosphonatoformate
3415 phosphonoformic acid
44561 trisodium phosphonatoformate
169569 trisodium phosphonatoformate hexahydrate
438229 sodium; azanide; phosphonatoformate; platinum(+4) cation
498371 azanide; phosphonoformic acid; platinum(+4) cation

internal high similarity DBLink | Rows returned: 0

active | Cluster 3362 | Additional Members: 1 | Rows returned: 0

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