| Compound Information | SONAR Target prediction |
| Name: | MEMANTINE HYDROCHLORIDE |
| Unique Identifier: | SPE01501121 |
| MolClass: | Checkout models in ver1.5 and ver1.0 |
| Molecular Formula: | |
| Molecular Weight: | 193.588 g/mol |
| X log p: | -0.844 (online calculus) |
| Lipinksi Failures | 0 |
| TPSA | 0 |
| Hydrogen Bond Donor Count: | 0 |
| Hydrogen Bond Acceptors Count: | 1 |
| Rotatable Bond Count: | 0 |
| Canonical Smiles: | Cl.CC12CC3CC(C)(C1)CC(N)(C3)C2 |
| Source: | synthetic |
| Therapeutics: | muscle relaxant (skeletal) |
| Generic_name: | Memantine |
| Chemical_iupac_name: | 3,5-dimethyladamantan-1-amine |
| Drug_type: | Approved Drug |
| Pharmgkb_id: | PA10364 |
| Kegg_compound_id: | C13736 |
| Drugbank_id: | APRD00221 |
| Melting_point: | 258 oC (HCl salt) |
| H2o_solubility: | 35 mg/mL (HCl salt), 0.9 mg/mL for free base |
| Logp: | 2.197 |
| Cas_registry_number: | 19982-08-2 |
| Drug_category: | Dopamine Agents; Antiparkinson Agents; Antidyskinetics; Excitatory Amino Acid Antagonists; Central Nervous System Agents; ATC:N06DX01 |
| Indication: | For the treatment of moderate to severe dementia of the Alzheimer-s type. |
| Pharmacology: | Memantine, an amantadine derivative, is an NMDA receptor antagonist used in the treatment of Alzheimer-s disease. It differs from traditional agents used in Alzheimer-s disease by acting on glutamatergic neurotransmission, rather than cholinergic. There is some evidence that dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is involved in the aetiology of Alzheimer-s disease (Cacabelos et al., 1999). As such, targeting the glutamatergic system, specifically NMDA receptors, was a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system. A systematic review of randomised controlled trials found that memantine has a positive effect on cognition, mood, behaviour, and the ability to perform daily activities. There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimer-s disease. |
| Mechanism_of_action: | Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Prolonged increased levels of glutamate in the brain of demented patients are sufficient to counter the voltage-dependent block of NMDA receptors by Mg2+ ions and allow continuous influx of Ca2+ ions into cells and ultimately neuronal degeneration. Studies suggest that memantine binds more effectively than Mg2+ ions at the NMDA receptor, and thereby effectively blocks this prolonged influx of Ca2+ ions through the NMDA channel whilst preserving the transient physiological activation of the channels by higher concentrations of synaptically released glutamate. Thus memantine protects against chronically elevated concentrations of glutamate. |
| Organisms_affected: | Humans and other mammals |
| Found: 205 nonactive as graph: single | with analogs | [1] << Back 31 32 33 34 35 36 37 38 39 40 Next >> [205] |
| Species: | 4932 |
| Condition: | KRE1 |
| Replicates: | 2 |
| Raw OD Value: r im | 0.6454±0.00480833 |
| Normalized OD Score: sc h | 0.9956±0.00252291 |
| Z-Score: | -0.1094±0.135658 |
| p-Value: | 0.913262 |
| Z-Factor: | -9.3349 |
| Fitness Defect: | 0.0907 |
| Bioactivity Statement: | Nonactive |
| ps |
| DBLink | Rows returned: 653 | [1] << Back 31 32 33 34 35 36 37 38 39 40 Next >> [109] |
| 492917 | (6S,7R)-7-ethyl-6-methyl-bicyclo[3.2.1]octan-8-amine |
| 492919 | (6R,7S)-6,7-diethylbicyclo[3.2.1]octan-8-amine |
| 492920 | 1-methylbicyclo[3.2.1]octan-8-amine |
| 492922 | (6R,7S)-1,6,7-trimethylbicyclo[3.2.1]octan-8-amine |
| 492932 | (4S,6R,7S)-1,6,7-trimethyl-4-propan-2-yl-bicyclo[3.2.1]octan-8-amine |
| 492937 | (2R,6R,7S)-6,7-dimethyl-2-propan-2-yl-bicyclo[3.2.1]octan-8-amine |
| internal high similarity DBLink | Rows returned: 12 | 1 2 Next >> |
| BTB 10381 | 1.0000 |
| RJC 04000 | 1.0000 |
| RH 01534 | 1.0000 |
| RDP 00128 | 1.0000 |
| LOPAC 00377 | 1.0000 |
| LOPAC 00361 | 1.0000 |
| active | Cluster 15523 | Additional Members: 3 | Rows returned: 0 |
Service provided by the
Mike Tyers Laboratory