Home | Screening data | Screen comparisons | Search for compounds | Structure search

Compound InformationSONAR Target prediction
Name:

FLUPHENAZINE HYDROCHLORIDE

Unique Identifier:SPE01500994
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:482.222 g/mol
X log p:16.56  (online calculus)
Lipinksi Failures1
TPSA35.02
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:4
Rotatable Bond Count:7
Canonical Smiles:Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Source:synthetic
Therapeutics:H1 antihistamine
Generic_name:Fluphenazine
Chemical_iupac_name:2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
Drug_type:Approved Drug
Pharmgkb_id:PA449676
Drugbank_id:APRD00633
Melting_point:< 25 oC
H2o_solubility:31.1 mg/L
Logp:4.552
Isoelectric_point:7.9
Cas_registry_number:69-23-8
Drug_category:Antipsychotics; Phenothiazines; ATC:N05AB02
Indication:For management of manifestations of psychotic disorders.
Pharmacology:Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the
management of schizophrenia and other psychotic disorders. Fluphenazine has not been
shown effective in the management of behaviorial complications in patients with
mental retardation.
Mechanism_of_action:Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the
brain; depresses the release of hypothalamic and hypophyseal hormones and is
believed to depress the reticular activating system thus affecting basal metabolism,
body temperature, wakefulness, vasomotor tone, and emesis.
Organisms_affected:Humans and other mammals

Found: 139 active | as graph: single | with analogs 2 3 4 5 6 7 8 9 10  Next >> [139]
Species: 4932
Condition: SPE01502260
Replicates: 2
Raw OD Value: r im 0.0452±0
Normalized OD Score: sc h 0.1261±0
Z-Score: -14.1587±0
p-Value: 2.8026e-45
Z-Factor: 0.795549
Fitness Defect: 102.5858
Bioactivity Statement: Toxic
Experimental Conditions
Library:SpectrumTMP
Plate Number and Position:2|C4
Drug Concentration:50.00 nM
OD Absorbance:0 nm
Robot Temperature:0.00 Celcius
Date:2006-08-13 YYYY-MM-DD
Plate CH Control (+):0.04055±0.00091
Plate DMSO Control (-):0.3584±0.02117
Plate Z-Factor:0.7899
png
ps
pdf

DBLink | Rows returned: 5
3372 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
67356 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride
657374 hydrogen(+1) cation; 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;
chloride
4427352 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-2,3,5,6-tetrahydropyrazin-1-yl]ethanol
6602611 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol hydrochloride

internal high similarity DBLink | Rows returned: 3
LOPAC 00319 0.9688
SPE01500591 0.9688
LOPAC 00285 1.0000

active | Cluster 6041 | Additional Members: 22 | Rows returned: 15<< Back 1 2 3
LAT004D07 0
LOPAC 00319 0
SPE01500591 0

Service provided by the Mike Tyers Laboratory