| Compound Information | SONAR Target prediction | | Name: | LATHOSTEROL | | Unique Identifier: | SPE01500843 | | MolClass: | Checkout models in ver1.5 and ver1.0 | | Molecular Formula: | | | Molecular Weight: | 341.296 g/mol | | X log p: | 3.679 (online calculus) | | Lipinksi Failures | 0 | | TPSA | 0 | | Hydrogen Bond Donor Count: | 0 | | Hydrogen Bond Acceptors Count: | 1 | | Rotatable Bond Count: | 5 | | Canonical Smiles: | CC(C)CCCC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C | | Class: | sterol | | Source: | Austeria rubens | | Reference: | J Biol Chem 248: 6697 (1973) | | Generic_name: | LANOSTEROL | | Chemical_iupac_name: | LANOSTEROL | | Drug_type: | Experimental | | Kegg_compound_id: | C01724 | | Drugbank_id: | EXPT02002 | | Logp: | 7.63 | | Cas_registry_number: | 79-63-0 | | Drug_category: | Lanosterol Synthase inhibitor | | Organisms_affected: | -1 |
| Species: |
4932 |
| Condition: |
RGP1 |
| Replicates: |
2 |
| Raw OD Value: r im |
0.3965±0.00622254 |
| Normalized OD Score: sc h |
0.8229±0.0199773 |
| Z-Score: |
-4.6220±0.459677 |
| p-Value: |
0.00000903334 |
| Z-Factor: |
0.0289704 |
| Fitness Defect: |
11.6146 |
| Bioactivity Statement: |
Active |
| Experimental Conditions | | | Library: | SPECMTS3 | | Plate Number and Position: | 22|A3 | | Drug Concentration: | 50.00 nM | | OD Absorbance: | 600 nm | | Robot Temperature: | 26.50 Celcius | | Date: | 2008-06-26 YYYY-MM-DD | | Plate CH Control (+): | 0.040025±0.00027 | | Plate DMSO Control (-): | 0.4675±0.01743 | | Plate Z-Factor: | 0.8726 |
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ps
pdf |
| 5321743 |
(3S,6bS,8aR,12S,12aR,14bS)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,7,8,9,10,11,12,12a,13,14,14a-tetra
decahydro-1H-picen-3-ol |
| 5358107 |
10,13-dimethyl-17-[(E)-3,4,5-trimethylhex-2-enyl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopent
a[a]phenanthren-3-ol |
| 5358162 |
17-[(E)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopen
ta[a]phenanthren-3-ol |
| 5365664 |
[(4E)-1-cyclooct-4-enyl]methanol |
| 5370331 |
(5Z)-6-methylcyclodec-5-en-1-ol |
| 5378246 |
4,10,13-trimethyl-17-[(E)-5-propan-2-ylhept-5-en-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cycl
openta[a]phenanthren-3-ol |
| internal high similarity DBLink | Rows returned: 11 | 1 2 Next >> |
| active | Cluster 14237 | Additional Members: 2 | Rows returned: 0 | |
|
