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Compound InformationSONAR Target prediction
Name:

AZELAIC ACID

Unique Identifier:SPE01500648
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:172.094 g/mol
X log p:-1.656  (online calculus)
Lipinksi Failures0
TPSA34.14
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:4
Rotatable Bond Count:8
Canonical Smiles:OC(=O)CCCCCCCC(O)=O
Class:alkane
Source:rancid fats and Lycopodium spp
Therapeutics:antiacne, antiproliferative agent
Generic_name:Azelaic Acid
Chemical_iupac_name:nonanedioic acid
Drug_type:Approved Drug
Pharmgkb_id:PA448516
Kegg_compound_id:C08261
Drugbank_id:APRD00812
Melting_point:106.5 oC
H2o_solubility:2400 mg/L (20°C)
Logp:1.646
Isoelectric_point:4.55
Cas_registry_number:123-99-9
Mass_spectrum:http://webbook.nist.gov/cgi/cbook.cgi?Spec=C123999&Index=0&Type=Mass&Large=on
Drug_category:Antineoplastic Agents; Dermatologic Agents; ATC:D10AX03
Indication:For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Pharmacology:Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and
barley. It is a natural substance that is produced by Malassezia furfur (also
known as Pityrosporum ovale), a yeast that lives on normal skin. It is
effective against a number of skin conditions, such as mild to moderate acne, when
applied topically in a cream formulation of 20%. It works in part by stopping the
growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic
acid-s antimicrobial action may be attributable to inhibition of microbial cellular
protein synthesis.
Mechanism_of_action:The exact mechanism of action of azelaic acid is not known. It is thought that
azelaic acid manifests its antibacterial effects by inhibiting the synthesis of
cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus
epidermidis
and Propionibacterium acnes. In aerobic bacteria, azelaic
acid reversibly inhibits several oxidoreductive enzymes including tyrosinase,
mitochondrial enzymes of the respiratory chain, thioredoxin reductase,
5-alpha-reductase, and DNA polymerases. In anaerobic bacteria, azelaic acid impedes
glycolysis. Along with these actions, azelaic acid also improves acne vulgaris by
normalizing the keratin process and decreasing microcomedo formation. Azelaic acid
may be effective against both inflamed and noninflamed lesions. Specifically,
azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin
granules by reducing the amount and distribution of filaggrin (a component of
keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules.
Organisms_affected:Various aerobic and anaerobic microorganisms

Found: 205 nonactive as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [205]
Species: 4932
Condition: MKK1
Replicates: 2
Raw OD Value: r im 0.8025±0.0883883
Normalized OD Score: sc h 0.9731±0.00843102
Z-Score: -0.7745±0.28346
p-Value: 0.447778
Z-Factor: -3.33685
Fitness Defect: 0.8035
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Spectrum_ED
Plate Number and Position:2|D8
Drug Concentration:50.00 nM
OD Absorbance:595 nm
Robot Temperature:30.00 Celcius
Date:2010-08-10 YYYY-MM-DD
Plate CH Control (+):0.09625±0.00864
Plate DMSO Control (-):0.9724999999999999±0.02659
Plate Z-Factor:0.8360
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DBLink | Rows returned: 2052[1] << Back 321 322 323 324 325 326 327 328 329 330  Next >> [342]
7173494 (3R,5S,7R,8S,9S,10R,13R,14R,17R)-17-[(2S)-4-carboxybutan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,1
5,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-dicarboxylic acid
7173509 (3R,5S,8R,9R,10S,12S,13R,14S,17R)-17-[(2S)-4-carboxylatobutan-2-yl]-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9
,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,12-dicarboxylate
7173510 (3R,5S,8R,9R,10S,12S,13R,14S,17R)-17-[(2S)-4-carboxybutan-2-yl]-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,
12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,12-dicarboxylic acid
7173512 (3R,5S,8R,9R,10S,12S,13R,14R,17R)-17-[(2S)-4-carboxylatobutan-2-yl]-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9
,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,12-dicarboxylate
7173513 (3R,5S,8R,9R,10S,12S,13R,14R,17R)-17-[(2S)-4-carboxybutan-2-yl]-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,
12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,12-dicarboxylic acid
7173514 (3R,5S,8R,9S,10S,12S,13R,14S,17R)-17-[(2S)-4-carboxylatobutan-2-yl]-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9
,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,12-dicarboxylate

internal high similarity DBLink | Rows returned: 292 3 4 5 Next >> 
JFD 01238 0.9524
SPE01500840 0.9524
SPE01500837 0.9524
SPE01500605 0.9524
SPE01500225 0.9524
SPE00270049 0.9524

active | Cluster 13528 | Additional Members: 3 | Rows returned: 0

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