| Compound Information | SONAR Target prediction |
| Name: | TROPICAMIDE |
| Unique Identifier: | SPE01500599 |
| MolClass: | Checkout models in ver1.5 and ver1.0 |
| Molecular Formula: | |
| Molecular Weight: | 264.194 g/mol |
| X log p: | 17.677 (online calculus) |
| Lipinksi Failures | 1 |
| TPSA | 32.67 |
| Hydrogen Bond Donor Count: | 0 |
| Hydrogen Bond Acceptors Count: | 4 |
| Rotatable Bond Count: | 7 |
| Canonical Smiles: | CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1 |
| Source: | synthetic |
| Therapeutics: | anticholinergic (opthalmic) |
| Generic_name: | Tropicamide |
| Chemical_iupac_name: | N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide |
| Drug_type: | Approved Drug |
| Pharmgkb_id: | PA451803 |
| Kegg_compound_id: | C07183 |
| Drugbank_id: | APRD00287 |
| Melting_point: | 96.5 oC |
| Logp: | 2.182 |
| Cas_registry_number: | 1508-75-4 |
| Mass_spectrum: | http://webbook.nist.gov/cgi/cbook.cgi?Spec=C1508754&Index=0&Type=Mass&Large=on |
| Drug_category: | Mydriatics; Muscarinic Antagonists; Diagnostic aid, cycloplegic; Diagnostic aid, mydriatic; ATC:S01FA06 |
| Indication: | Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye. |
| Pharmacology: | Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly. |
| Mechanism_of_action: | Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle. |
| Organisms_affected: | Humans and other mammals |
| Found: 205 nonactive as graph: single | with analogs | 1 2 3 4 5 6 7 8 9 10 Next >> [205] |
| Species: | 4932 |
| Condition: | BCK1 |
| Replicates: | 2 |
| Raw OD Value: r im | 0.9210±0.00770746 |
| Normalized OD Score: sc h | 0.9980±0.00744693 |
| Z-Score: | -0.5447±0.15516 |
| p-Value: | 0.58819 |
| Z-Factor: | -6.66253 |
| Fitness Defect: | 0.5307 |
| Bioactivity Statement: | Nonactive |
| ps |
| DBLink | Rows returned: 3 |
| 5593 | N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide |
| 688595 | (2R)-N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide |
| 688596 | (2S)-N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide |
| internal high similarity DBLink | Rows returned: 1 |
| LOPAC 00240 | 1.0000 |
| active | Cluster 7376 | Additional Members: 4 | Rows returned: 0 |
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