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Compound InformationSONAR Target prediction
Name:

DIPHENYLPYRALINE HYDROCHLORIDE

Unique Identifier:SPE01500258
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:293.662 g/mol
X log p:21.016  (online calculus)
Lipinksi Failures1
TPSA12.47
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:2
Rotatable Bond Count:4
Canonical Smiles:Cl.CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Source:synthetic
Therapeutics:antihistaminic
Generic_name:Diphenylpyraline
Chemical_iupac_name:4-benzhydryloxy-1-methyl-piperidine
Drug_type:Approved Drug
Drugbank_id:APRD00719
Logp:4.325
Cas_registry_number:147-20-6
Drug_category:Antihistamines; ATC:R06AA07
Indication:For use in the treatment of allergic rhinitis, hay fever, and allergic skin
disorders.
Pharmacology:Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses
mediated by histamine alone. Diphenylpyraline antagonizes most of the
pharmacological effects of histamine, including urticaria and pruritus. Also,
diphenylpyraline may exhibit anticholinergic actions (as do most of the
antihistamines) and may thus provide a drying effect on the nasal mucosa.
Mechanism_of_action:Antihistamines such as diphenylpyraline used in the treatment of allergy act by
competing with histamine for H1-receptor sites on effector cells. This reduces the
effects of histamine, leading to a temporary reduction of allergy symptoms.
Organisms_affected:Humans and other mammals

Found: 205 nonactive as graph: single | with analogs [1] << Back 11 12 13 14 15 16 17 18 19 20  Next >> [205]
Species: 4932
Condition: SLT2
Replicates: 2
Raw OD Value: r im 0.8755±0.00282843
Normalized OD Score: sc h 0.9973±0.00236608
Z-Score: -0.0874±0.116921
p-Value: 0.930598
Z-Factor: -128.305
Fitness Defect: 0.0719
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Spectrum_ED
Plate Number and Position:2|F10
Drug Concentration:50.00 nM
OD Absorbance:595 nm
Robot Temperature:30.00 Celcius
Date:2010-08-10 YYYY-MM-DD
Plate CH Control (+):0.08625±0.00492
Plate DMSO Control (-):0.96725±0.02708
Plate Z-Factor:0.8577
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DBLink | Rows returned: 3
3103 4-benzhydryloxy-1-methyl-piperidine
66063 4-benzhydryloxy-1-methyl-piperidine hydrochloride
3668575 4-benzhydryloxy-1-methyl-3,4,5,6-tetrahydro-2H-pyridine

internal high similarity DBLink | Rows returned: 0

nonactive | Cluster 2609 | Additional Members: 7 | Rows returned: 6
Prest969 0.448979591836735
LOPAC 00168 0.326923076923077
SPE02300334 0.326923076923077
LOPAC 00255 0.170212765957447
SPE01500142 0
LOPAC 00174 0

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