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Compound InformationSONAR Target prediction
Name:

CHLORTETRACYCLINE HYDROCHLORIDE

Unique Identifier:SPE01500186
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:455.697 g/mol
X log p:3.2  (online calculus)
Lipinksi Failures0
TPSA54.45
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:10
Rotatable Bond Count:2
Canonical Smiles:CN(C)C1C2CC3C(=C(O)C2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)ccc(Cl)c1C3(C)O
Class:quinone
Source:Streptomyces aureofaciens
Reference:Ann NY Acad Sci 51: 177 (1948); JACS 74: 4976 (1952); 76: 3568 (1954)
Therapeutics:antibacterial, antiamebic, Ca chelator, hepatotoxic; inhibits protein synthesis
Generic_name:7-CHLOROTETRACYCLINE
Chemical_iupac_name:7-CHLOROTETRACYCLINE
Drug_type:Experimental
Drugbank_id:EXPT01049
Drug_category:Tetracycline Repressor inhibitor
Organisms_affected:-1

Found: 205 nonactive as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [205]
Species: 4932
Condition: MKK1
Replicates: 2
Raw OD Value: r im 0.8975±0.0841457
Normalized OD Score: sc h 1.0490±0.0121759
Z-Score: 1.4110±0.425601
p-Value: 0.176947
Z-Factor: -1.33154
Fitness Defect: 1.7319
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Spectrum_ED
Plate Number and Position:1|G8
Drug Concentration:50.00 nM
OD Absorbance:595 nm
Robot Temperature:30.00 Celcius
Date:2010-08-10 YYYY-MM-DD
Plate CH Control (+):0.09525±0.00506
Plate DMSO Control (-):0.9664999999999999±0.02195
Plate Z-Factor:0.8798
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DBLink | Rows returned: 0

internal high similarity DBLink | Rows returned: 5
SPE01500457 0.9146
SPE01500566 0.9298
LOPAC 00845 1.0000
SPE01500226 1.0000
SPE01500829 1.0000

active | Cluster 12393 | Additional Members: 20 | Rows returned: 4
Prest1244 0.490196078431373
Prest1045 0.452631578947368
SPE01505684 0.452631578947368
Prest60 0

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