Home | Screening data | Screen comparisons | Search for compounds | Structure search

Compound InformationSONAR Target prediction
Name:

CHLORPROPAMIDE

Unique Identifier:SPE01500185
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:263.637 g/mol
X log p:7.851  (online calculus)
Lipinksi Failures1
TPSA59.59
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:5
Rotatable Bond Count:6
Canonical Smiles:CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
Source:synthetic
Therapeutics:antidiabetic
Generic_name:Chlorpropamide
Chemical_iupac_name:N-(4-chlorophenyl)sulfonylmethanamide
Drug_type:Approved Drug
Pharmgkb_id:PA448966
Kegg_compound_id:C06907
Drugbank_id:APRD00029
Melting_point:127 - 129 oC
H2o_solubility:Solubility at pH 6 is 2.2 mg/ml
Logp:2.653
Cas_registry_number:94-20-2
Mass_spectrum:http://webbook.nist.gov/cgi/cbook.cgi?Spec=C94202&Index=0&Type=Mass&Large=on
Drug_category:Hypoglycemic Agents; Sulfonylureas; ATC:A10BB02
Indication:For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM).
Pharmacology:Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with
diet to lower blood glucose levels in patients with diabetes mellitus type II.
Chlorpropamide is twice as potent as the related second-generation agent glipizide.
Mechanism_of_action:Sulfonylureas such as Chlorpropamide likely bind to ATP-sensitive potassium-channel
receptors on the pancreatic cell surface, reducing potassium conductance and causing
depolarization of the membrane. Depolarization stimulates calcium ion influx through
voltage-sensitive calcium channels, raising intracellular concentrations of calcium
ions, which induces the secretion, or exocytosis, of insulin.
Organisms_affected:Humans and other mammals

Found: 205 nonactive as graph: single | with analogs [1] << Back 71 72 73 74 75 76 77 78 79 80  Next >> [205]
Species: 4932
Condition: SWI4
Replicates: 2
Raw OD Value: r im 0.5839±0.00749533
Normalized OD Score: sc h 1.0159±0.0116792
Z-Score: 0.7053±0.535835
p-Value: 0.511198
Z-Factor: -6.59752
Fitness Defect: 0.671
Bioactivity Statement: Nonactive
Experimental Conditions
Library:SPECMTS3
Plate Number and Position:4|C2
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:26.00 Celcius
Date:2008-02-07 YYYY-MM-DD
Plate CH Control (+):0.041075±0.00049
Plate DMSO Control (-):0.5689500000000001±0.01426
Plate Z-Factor:0.9136
png
ps
pdf

DBLink | Rows returned: 3
2727 1-(4-chlorophenyl)sulfonyl-3-propyl-urea
253746 1-(4-chlorophenyl)sulfonyl-3-cyclopropyl-urea
3040371 1-(4-chlorophenyl)sulfonyl-3-(2-methylpropyl)urea

internal high similarity DBLink | Rows returned: 1
LOPAC 00030 1.0000

nonactive | Cluster 17828 | Additional Members: 9 | Rows returned: 5
LOPAC 00077 0.44
SPE01500581 0.44
Prest471 0.44
Prest684 0
LOPAC 00030 0

Service provided by the Mike Tyers Laboratory