Home | Screening data | Screen comparisons | Search for compounds | Structure search

Compound InformationSONAR Target prediction
Name:

EUPHOL

Unique Identifier:SPE00201697
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:376.32 g/mol
X log p:2.412  (online calculus)
Lipinksi Failures0
TPSA0
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:1
Rotatable Bond Count:4
Canonical Smiles:CC(CCC=C(C)C)C1CCC2(C)C3CCC4C(C)(C)C(O)CCC4(C)C=3CCC12C
Class:triterpene
Source:Euphorbia spp.
Reference:J Chem Soc 1944:249; 1958:179
Generic_name:LANOSTEROL
Chemical_iupac_name:LANOSTEROL
Drug_type:Experimental
Kegg_compound_id:C01724
Drugbank_id:EXPT02002
Logp:7.63
Cas_registry_number:79-63-0
Drug_category:Lanosterol Synthase inhibitor
Organisms_affected:-1

Found: 52 active | as graph: single | with analogs [1] << Back 21 22 23 24 25 26 27 28 29 30  Next >> [52]
Species: 4932
Condition: SER1
Replicates: 2
Raw OD Value: r im 0.4794±0.0265165
Normalized OD Score: sc h 0.8501±0.0329453
Z-Score: -4.7093±0.908511
p-Value: 0.0000238642
Z-Factor: -7.56888
Fitness Defect: 10.6431
Bioactivity Statement: Active
Experimental Conditions
Library:Spectrum
Plate Number and Position:4|B2
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:26.20 Celcius
Date:2007-09-17 YYYY-MM-DD
Plate CH Control (+):0.03955±0.00064
Plate DMSO Control (-):0.597125±0.11510
Plate Z-Factor:0.3000
png
ps
pdf

DBLink | Rows returned: 2772 3 4 5 6 7 8 9 10  Next >> [47]
330 10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenan
thren-3-ol
420 10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenan
thren-3-ol
856 4,4,10,13,14-pentamethyl-17-(6-methylhept-5-en-2-yl)-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]
phenanthren-3-ol
3882 4,4,10,13,14,17-hexamethyl-17-(6-methylhept-5-en-2-yl)-1,2,3,5,6,7,11,12,15,16-decahydrocyclopenta[a]phe
nanthren-3-ol
6606 (3S,5S,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-(6-methylhept-5-en-2-yl)-2,3,5,6,7,11,12,15,16,17-de
cahydro-1H-cyclopenta[a]phenanthren-3-ol
65172 (3S,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methyl-5-methylidene-heptan-2-yl]-2,3,5,6,7,11,
12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol

internal high similarity DBLink | Rows returned: 112 Next >> 
SPE01504073 0.9167
SPE01504051 0.9189
SPE01500847 0.9189
SPE00107022 0.9189
SPE00300055 0.9444
NRB 03722 0.9706

nonactive | Cluster 1278 | Additional Members: 6 | Rows returned: 4
SPE00201696 0.253012048192771
SPE00100583 0.253012048192771
SPE00240449 0.243589743589744
SPE00240470 0

Service provided by the Mike Tyers Laboratory