Home | Screening data | Screen comparisons | Search for compounds | Structure search

Compound InformationSONAR Target prediction
Name:

EUPHOL

Unique Identifier:SPE00201697
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:376.32 g/mol
X log p:2.412  (online calculus)
Lipinksi Failures0
TPSA0
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:1
Rotatable Bond Count:4
Canonical Smiles:CC(CCC=C(C)C)C1CCC2(C)C3CCC4C(C)(C)C(O)CCC4(C)C=3CCC12C
Class:triterpene
Source:Euphorbia spp.
Reference:J Chem Soc 1944:249; 1958:179
Generic_name:LANOSTEROL
Chemical_iupac_name:LANOSTEROL
Drug_type:Experimental
Kegg_compound_id:C01724
Drugbank_id:EXPT02002
Logp:7.63
Cas_registry_number:79-63-0
Drug_category:Lanosterol Synthase inhibitor
Organisms_affected:-1

Found: 52 active | as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [52]
Species: 4932
Condition: SPE00307050
Replicates: 2
Raw OD Value: r im 0.2369±0
Normalized OD Score: sc h 0.6725±0
Z-Score: -7.2217±0
p-Value: 0.00000000000051336
Z-Factor: 0.767971
Fitness Defect: 28.2978
Bioactivity Statement: Active
Experimental Conditions
Library:SpectrumTMP
Plate Number and Position:1|C8
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:0.00 Celcius
Date:2006-08-17 YYYY-MM-DD
Plate CH Control (+):0.04065±0.00251
Plate DMSO Control (-):0.35225±0.00896
Plate Z-Factor:0.8897
png
ps
pdf

DBLink | Rows returned: 277[1] << Back 31 32 33 34 35 36 37 38 39 40  Next >> [47]
5379721 17-[(E)-5,6-dimethylhept-4-en-2-yl]-10,13,14-trimethyl-1,2,3,4,5,6,7,11,12,15,16,17-dodecahydrocyclopent
a[a]phenanthren-3-ol
5459827 (3S,5S,9R,10R,13S,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17
-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
5460076 (3S,5S,9R,10S,13S,14R,17R)-4,4,10,13-tetramethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,5,6,9,11,12,14,15,1
6,17-dodecahydrocyclopenta[a]phenanthren-3-ol
5492463 (3S,5S,9R,10R,13S,14R,17R)-17-[(2R,5R)-5-ethyl-7-methyl-6-methylidene-octan-2-yl]-10,13-dimethyl-2,3,4,5
,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
6321372 (3S,5S,9R,10R,13S,14R,17R)-17-[(2R,5R)-5-ethyl-6-methyl-hept-6-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12
,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
6370213 10,13-dimethyl-17-[(E)-3,4,5-trimethylhex-2-enyl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopent
a[a]phenanthren-3-ol

internal high similarity DBLink | Rows returned: 112 Next >> 
SPE01504073 0.9167
SPE01504051 0.9189
SPE01500847 0.9189
SPE00107022 0.9189
SPE00300055 0.9444
NRB 03722 0.9706

active | Cluster 1278 | Additional Members: 6 | Rows returned: 2
SPE00100583 0.253012048192771
SPE00240470 0

Service provided by the Mike Tyers Laboratory