Compound Information | SONAR Target prediction | Name: | EUPHOL | Unique Identifier: | SPE00201697 | MolClass: | Checkout models in ver1.5 and ver1.0 | Molecular Formula: | | Molecular Weight: | 376.32 g/mol | X log p: | 2.412 (online calculus) | Lipinksi Failures | 0 | TPSA | 0 | Hydrogen Bond Donor Count: | 0 | Hydrogen Bond Acceptors Count: | 1 | Rotatable Bond Count: | 4 | Canonical Smiles: | CC(CCC=C(C)C)C1CCC2(C)C3CCC4C(C)(C)C(O)CCC4(C)C=3CCC12C | Class: | triterpene | Source: | Euphorbia spp. | Reference: | J Chem Soc 1944:249; 1958:179 | Generic_name: | LANOSTEROL | Chemical_iupac_name: | LANOSTEROL | Drug_type: | Experimental | Kegg_compound_id: | C01724 | Drugbank_id: | EXPT02002 | Logp: | 7.63 | Cas_registry_number: | 79-63-0 | Drug_category: | Lanosterol Synthase inhibitor | Organisms_affected: | -1 |
Species: |
4932 |
Condition: |
SPE01502260 |
Replicates: |
2 |
Raw OD Value: r im |
0.2086±0 |
Normalized OD Score: sc h |
0.6140±0 |
Z-Score: |
-6.2543±0 |
p-Value: |
0.00000000039931 |
Z-Factor: |
0.661671 |
Fitness Defect: |
21.6413 |
Bioactivity Statement: |
Active |
Experimental Conditions | | Library: | SpectrumTMP | Plate Number and Position: | 1|C8 | Drug Concentration: | 50.00 nM | OD Absorbance: | 0 nm | Robot Temperature: | 0.00 Celcius | Date: | 2006-08-13 YYYY-MM-DD | Plate CH Control (+): | 0.04065±0.00109 | Plate DMSO Control (-): | 0.33975±0.01459 | Plate Z-Factor: | 0.8418 |
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5379721 |
17-[(E)-5,6-dimethylhept-4-en-2-yl]-10,13,14-trimethyl-1,2,3,4,5,6,7,11,12,15,16,17-dodecahydrocyclopent a[a]phenanthren-3-ol |
5459827 |
(3S,5S,9R,10R,13S,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17 -dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
5460076 |
(3S,5S,9R,10S,13S,14R,17R)-4,4,10,13-tetramethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,5,6,9,11,12,14,15,1 6,17-dodecahydrocyclopenta[a]phenanthren-3-ol |
5492463 |
(3S,5S,9R,10R,13S,14R,17R)-17-[(2R,5R)-5-ethyl-7-methyl-6-methylidene-octan-2-yl]-10,13-dimethyl-2,3,4,5 ,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
6321372 |
(3S,5S,9R,10R,13S,14R,17R)-17-[(2R,5R)-5-ethyl-6-methyl-hept-6-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12 ,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
6370213 |
10,13-dimethyl-17-[(E)-3,4,5-trimethylhex-2-enyl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopent a[a]phenanthren-3-ol |
internal high similarity DBLink | Rows returned: 11 | << Back 1 2 |
active | Cluster 1278 | Additional Members: 6 | Rows returned: 2 | |
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