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Compound InformationSONAR Target prediction
Name:

Promazine hydrochloride

Unique Identifier:Prest974
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C17ClH21N2S
Molecular Weight:299.714 g/mol
X log p:17.925  (online calculus)
Lipinksi Failures1
TPSA31.78
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:2
Rotatable Bond Count:4
Canonical Smiles:Cl.CN(C)CCCN1c2ccccc2Sc2ccccc12
Generic_name:Trimeprazine
Chemical_iupac_name:N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
Drug_type:Approved Drug
Pharmgkb_id:PA451781
Kegg_compound_id:C07172
Drugbank_id:APRD00258
Melting_point:68 oC
H2o_solubility:0.942 mg/L
Logp:5.162
Isoelectric_point:9.05
Cas_registry_number:84-96-8
Mass_spectrum:http://webbook.nist.gov/cgi/cbook.cgi?Spec=C84968&Index=0&Type=Mass&Large=on
Drug_category:Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05
Indication:Used to prevent and relieve allergic conditions which cause pruritus (itching) and
urticaria (some allergic skin reactions).
Pharmacology:Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in
structure to the phenothiazine antipsychotics, but differing in the
ring-substitution and chain characteristics. Trimeprazine is in the same class of
drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike
the other drugs in this class, trimeprazine is not used clinically as an
anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic
(anti-nausea). Trimeprazine is used principally as an anti-emetic, to prevent motion
sickness or as an anti-histamine in combination with other medications in cough and
cold preparations. Tricyclic antihistamines are also structurally-related to the
tricyclic antidepressants, explaining the antihistaminergic adverse effects of these
two drug classes and also the poor tolerability profile of tricyclic
H1-antihistamines.
Mechanism_of_action:Trimeprazine competes with free histamine for binding at HA-receptor sites. This
antagonizes the effects of histamine on HA-receptors, leading to a reduction of the
negative symptoms brought on by histamine HA-receptor binding.
Organisms_affected:Humans and other mammals

Found: 3 nonactive as graph: single | with analogs 2 3 Next >> 
Species: 9606
Condition: TMPPre001
Replicates: 2
Raw OD Value: r im 1923.0000±0
Normalized OD Score: sc h 0.9376±0
Z-Score: -1.4065±0
p-Value: 0.159575
Z-Factor: -25.4285
Fitness Defect: 1.8352
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Prestwick
Plate Number and Position:9|F4
Drug Concentration:50.00 nM
OD Absorbance:0 nm
Robot Temperature:24.30 Celcius
Date:2006-10-10 YYYY-MM-DD
Plate CH Control (+):934.5±887.42587
Plate DMSO Control (-):1947.5±635.64730
Plate Z-Factor:-4.7271
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DBLink | Rows returned: 122 Next >> 
4926 N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine
5574 N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
5887 N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine hydrochloride
28315 N-methyl-3-phenothiazin-10-yl-propan-1-amine
78038 N,N,2,2-tetramethyl-3-phenothiazin-10-yl-propan-1-amine
102719 N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine hydrochloride

internal high similarity DBLink | Rows returned: 0

active | Cluster 17541 | Additional Members: 13 | Rows returned: 4
SPE01503934 0.32258064516129
SPE01500184 0
LAT005D03 0
LOPAC 00253 0

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