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Compound InformationSONAR Target prediction
Name:

Diphenylpyraline hydrochloride

Unique Identifier:Prest969
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C19ClH24NO
Molecular Weight:293.662 g/mol
X log p:21.016  (online calculus)
Lipinksi Failures1
TPSA12.47
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:2
Rotatable Bond Count:4
Canonical Smiles:Cl.CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Generic_name:Diphenylpyraline
Chemical_iupac_name:4-benzhydryloxy-1-methyl-piperidine
Drug_type:Approved Drug
Drugbank_id:APRD00719
Logp:4.325
Cas_registry_number:147-20-6
Drug_category:Antihistamines; ATC:R06AA07
Indication:For use in the treatment of allergic rhinitis, hay fever, and allergic skin
disorders.
Pharmacology:Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses
mediated by histamine alone. Diphenylpyraline antagonizes most of the
pharmacological effects of histamine, including urticaria and pruritus. Also,
diphenylpyraline may exhibit anticholinergic actions (as do most of the
antihistamines) and may thus provide a drying effect on the nasal mucosa.
Mechanism_of_action:Antihistamines such as diphenylpyraline used in the treatment of allergy act by
competing with histamine for H1-receptor sites on effector cells. This reduces the
effects of histamine, leading to a temporary reduction of allergy symptoms.
Organisms_affected:Humans and other mammals

Found: 3 nonactive as graph: single | with analogs 2 3 Next >> 
Species: 9606
Condition: TMPPre001
Replicates: 2
Raw OD Value: r im 2074.0000±0
Normalized OD Score: sc h 1.0282±0
Z-Score: 0.6351±0
p-Value: 0.525354
Z-Factor: -6.67216
Fitness Defect: 0.6437
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Prestwick
Plate Number and Position:9|G8
Drug Concentration:50.00 nM
OD Absorbance:0 nm
Robot Temperature:24.30 Celcius
Date:2006-10-10 YYYY-MM-DD
Plate CH Control (+):934.5±887.42587
Plate DMSO Control (-):1947.5±635.64730
Plate Z-Factor:-4.7271
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DBLink | Rows returned: 3
3103 4-benzhydryloxy-1-methyl-piperidine
66063 4-benzhydryloxy-1-methyl-piperidine hydrochloride
3668575 4-benzhydryloxy-1-methyl-3,4,5,6-tetrahydro-2H-pyridine

internal high similarity DBLink | Rows returned: 0

nonactive | Cluster 2609 | Additional Members: 7 | Rows returned: 6
SPE01500258 0.448979591836735
LOPAC 00168 0.326923076923077
SPE02300334 0.326923076923077
LOPAC 00255 0.170212765957447
SPE01500142 0
LOPAC 00174 0

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