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Compound InformationSONAR Target prediction
Name:

Cyclosporin A

Unique Identifier:Prest731
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C62H111N11O12
Molecular Weight:1091.74 g/mol
X log p:0.0189999999999997  (online calculus)
Lipinksi Failures2
TPSA210.45
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:23
Rotatable Bond Count:15
Canonical Smiles:CCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)
C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C
)C)N(C)C(=O)CN(C)C1=O)C(C)C
Generic_name:Cyclosporine
Chemical_iupac_name:Cyclosporine
Drug_type:Approved Drug
Pharmgkb_id:PA449167
Drugbank_id:BIOD00003
Logp:4.293
Cas_registry_number:59865-13-3
Drug_category:Immunmodulatory Agents; Immunosupressants
Indication:For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis
Pharmacology:Used in immunosuppression for prophylactic treatment of organ transplants,
cyclosporine exerts specific and reversible inhibition of immunocompetent
lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are
preferentially inhibited. The T1-helper cell is the main target, although the
T1-suppressor cell may also be suppressed. Sandimmune (cyclosporine) also inhibits
lymphokine production and release including interleukin-2.
Mechanism_of_action:Cyclosporine binds to cyclophillin. The complex then inhibits calcineurin which is
normally responsible for activating transcription of interleukin 2. Cyclosporine
also inhibits lymphokine production and ineterluekin relase.
Organisms_affected:Humans and other mammals

Found: 3 nonactive as graph: single | with analogs 2 3 Next >> 
Species: 9606
Condition: TMPPre001
Replicates: 2
Raw OD Value: r im 1772.0000±0
Normalized OD Score: sc h 0.8453±0
Z-Score: -3.4868±0
p-Value: 0.000488772
Z-Factor: -10.8442
Fitness Defect: 7.6236
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Prestwick
Plate Number and Position:6|D6
Drug Concentration:50.00 nM
OD Absorbance:0 nm
Robot Temperature:24.00 Celcius
Date:2006-10-10 YYYY-MM-DD
Plate CH Control (+):1009.5±953.84240
Plate DMSO Control (-):2021±558.06298
Plate Z-Factor:-4.4864
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DBLink | Rows returned: 42<< Back 1 2 3 4 5 6 7 Next >> 
5287817 (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-(1-hydroxyethyl)-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-
1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,
19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
5287819 (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25
,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tripropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-u
ndecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
5288089 (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R)-1-hydroxy-2,2-dimethyl-hex-4-enyl]-1,4,7,10,1
2,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,2
8,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
5458585 30-ethyl-33-[(E,1S,2S)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetra
kis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,1
1,14,17,20,23,26,29,32-undecone
5497195 30-ethyl-33-[(E,1S,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetra
kis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,1
1,14,17,20,23,26,29,32-undecone
6426614 30-ethyl-33-[(E)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,18,24-tris(2-methyl
propyl)-3,21-dipropan-2-yl-9-tert-butyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,
11,14,17,20,23,26,29,32-undecone

internal high similarity DBLink | Rows returned: 0

active | Cluster 1190 | Additional Members: 4 | Rows returned: 1
SPE01502202 0

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