| Compound Information | SONAR Target prediction |
| Name: | Sulfanilamide |
| Unique Identifier: | Prest36 |
| MolClass: | Checkout models in ver1.5 and ver1.0 |
| Molecular Formula: | C6H8N2O2S |
| Molecular Weight: | 164.142 g/mol |
| X log p: | 6.783 (online calculus) |
| Lipinksi Failures | 1 |
| TPSA | 42.52 |
| Hydrogen Bond Donor Count: | 0 |
| Hydrogen Bond Acceptors Count: | 4 |
| Rotatable Bond Count: | 1 |
| Canonical Smiles: | Nc1ccc(cc1)S(N)(=O)=O |
| Generic_name: | Sulfanilamide |
| Chemical_iupac_name: | 4-aminobenzenesulfonamide |
| Drug_type: | Approved Drug |
| Pharmgkb_id: | PA451545 |
| Kegg_compound_id: | C07458 |
| Drugbank_id: | APRD00438 |
| Melting_point: | 165.5 oC |
| H2o_solubility: | 7500 mg/L |
| Logp: | -0.201 |
| Isoelectric_point: | 10.6 |
| Cas_registry_number: | 63-74-1 |
| Mass_spectrum: | http://webbook.nist.gov/cgi/cbook.cgi?Spec=C63741&Index=0&Type=Mass&Large=on |
| Drug_category: | Anti-bacterial Agents; Homeopathic Agents; ATC:J01EB06; ATC:D06BA05 |
| Indication: | For the treatment of vulvovaginitis caused by Candida albicans. |
| Pharmacology: | Sulfanilamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. |
| Mechanism_of_action: | Sulfanilamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. |
| Organisms_affected: | Candida albicans and other yeasts |
| Found: 3 nonactive as graph: single | with analogs | 1 2 3 Next >> |
| Species: | 9606 |
| Condition: | TMPPre001 |
| Replicates: | 2 |
| Raw OD Value: r im | 1013.0000±0 |
| Normalized OD Score: sc h | 0.9410±0 |
| Z-Score: | -1.3310±0 |
| p-Value: | 0.183203 |
| Z-Factor: | -13.9765 |
| Fitness Defect: | 1.6972 |
| Bioactivity Statement: | Nonactive |
| ps |
| DBLink | Rows returned: 4 |
| 5333 | 4-aminobenzenesulfonamide |
| 24941 | sodium (4-aminophenyl)sulfonylazanide |
| 80197 | 4-aminobenzenesulfonamide hydrochloride |
| 5042741 | (4-azaniumylphenyl)sulfonylazanium |
| internal high similarity DBLink | Rows returned: 0 |
| active | Cluster 8643 | Additional Members: 6 | Rows returned: 0 |
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