| Compound Information | SONAR Target prediction |
| Name: | Propofol |
| Unique Identifier: | Prest1289 |
| MolClass: | Checkout models in ver1.5 and ver1.0 |
| Molecular Formula: | C12H18O |
| Molecular Weight: | 160.128 g/mol |
| X log p: | 6.474 (online calculus) |
| Lipinksi Failures | 1 |
| TPSA | 0 |
| Hydrogen Bond Donor Count: | 0 |
| Hydrogen Bond Acceptors Count: | 1 |
| Rotatable Bond Count: | 2 |
| Canonical Smiles: | CC(C)c1cccc(C(C)C)c1O |
| Generic_name: | Propofol |
| Chemical_iupac_name: | 2,6-dipropan-2-ylphenol |
| Drug_type: | Approved Drug |
| Pharmgkb_id: | PA451141 |
| Kegg_compound_id: | C07523 |
| Drugbank_id: | APRD01201 |
| Melting_point: | 18 oC |
| H2o_solubility: | 124 mg/L |
| Logp: | 3.842 |
| Isoelectric_point: | 11.1 |
| Cas_registry_number: | 2078-54-8 |
| Mass_spectrum: | http://webbook.nist.gov/cgi/cbook.cgi?Spec=C2078548&Index=0&Type=Mass&Large=on |
| Drug_category: | Anesthetics, Intravenous; Anticonvulsants; Antiemetics; Free Radical Scavengers;
Hypnotics and Sedatives; ATC:N01AX10 |
| Indication: | Used for both induction and/or maintenance of anesthesia. |
| Pharmacology: | Propofol a sedative-hypnotic agent for use in the induction and maintenance of
anesthesia or sedation. Intravenous injection of a therapeutic dose of propofol
produces hypnosis rapidly with minimal excitation, usually within 40 seconds from
the start of an injection (the time for one arm-brain circulation). |
| Mechanism_of_action: | The action of propofol involves a positive modulation of the inhibitory function of
the neurotransmitter gama-aminobutyric acid(GABA) through GABA-A receptors. |
| Organisms_affected: | Humans and other mammals |
