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Compound InformationSONAR Target prediction
Name:

Furazolidone

Unique Identifier:Prest1067
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C8H7N3O5
Molecular Weight:218.103 g/mol
X log p:6.981  (online calculus)
Lipinksi Failures1
TPSA94.27
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:5
Rotatable Bond Count:3
Canonical Smiles:[O-][N+](=O)c1oc(cc1)C=NN1CCOC1=O
Generic_name:Furazolidone
Chemical_iupac_name:3-[(5-nitro-2-furyl)methylideneamino]oxazolidin-2-one
Drug_type:Approved Drug
Pharmgkb_id:PA449718
Kegg_compound_id:C07999
Drugbank_id:APRD00988
Melting_point:255 oC
H2o_solubility:40 mg/L
Logp:0.691
Cas_registry_number:67-45-8
Drug_category:Anti-Infective Agents, Local; Anti-Infective Agents, Urinary; Antitrichomonal
Agents; Monoamine Oxidase Inhibitors; ATC:G01AX06
Indication:For the specific and symptomatic treatment of bacterial or protozoal diarrhea and
enteritis caused by susceptible organisms.
Pharmacology:Furoxone has a broad antibacterial spectrum covering the majority of
gastrointestinal tract pathogens including E. coli, staphylococci, Salmonella,
Shigella, Proteus, Aerobacter aerogenes, Vibrio cholerae and Giardia lamblia. Its
bactericidal activity is based upon its interference with DNA replication and
protein production; this antimicrobial action minimizes the development of resistant
organisms.
Mechanism_of_action:Furazolidone and its related free radical products are believed to bind DNA and
induce cross-links. Bacterial DNA is particularly susceptible to this drug leading
to high levels of mutations (transitions and transversions) in the bacterial
chromosome.
Organisms_affected:Microbes (bacteria, parasites)

Found: 3 active as graph: single | with analogs << Back 1 2 3 Next >> 
Species: 9606
Condition: TMPPre002
Replicates: 2
Raw OD Value: r im 5510.0000±0
Normalized OD Score: sc h 0.8117±0
Z-Score: -4.2438±0
p-Value: 0.0000219748
Z-Factor: -3.40302
Fitness Defect: 10.7256
Bioactivity Statement: Active
Experimental Conditions
Library:Prestwick
Plate Number and Position:11|A9
Drug Concentration:50.00 nM
OD Absorbance:0 nm
Robot Temperature:23.20 Celcius
Date:2006-10-10 YYYY-MM-DD
Plate CH Control (+):853.5±701.09504
Plate DMSO Control (-):849±311.18603
Plate Z-Factor:-72.3031
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DBLink | Rows returned: 4
3435 3-[(5-nitro-2-furyl)methylideneamino]oxazolidin-2-one
5323714 3-[(5-nitro-2-furyl)methylideneamino]oxazolidin-2-one
5353636 3-[(5-nitro-2-furyl)methylideneamino]oxazolidin-2-one
6837169 hydroxy-oxo-[5-[(2-oxooxazolidin-3-yl)iminomethyl]-2-furyl]azanium

internal high similarity DBLink | Rows returned: 0

active | Cluster 4702 | Additional Members: 3 | Rows returned: 1
SPE01500309 0

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