Home | Screening data | Screen comparisons | Search for compounds | Structure search

Compound InformationSONAR Target prediction
Name:

Promazine hydrochloride

Unique Identifier:LOPAC 01148
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C17ClH21N2S
Molecular Weight:299.714 g/mol
X log p:17.925  (online calculus)
Lipinksi Failures1
TPSA31.78
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:2
Rotatable Bond Count:4
Canonical Smiles:Cl.CN(C)CCCN1c2ccccc2Sc2ccccc12
Class:Dopamine
Action:Antagonist
Selectivity:DRD2
Generic_name:Trimeprazine
Chemical_iupac_name:N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
Drug_type:Approved Drug
Pharmgkb_id:PA451781
Kegg_compound_id:C07172
Drugbank_id:APRD00258
Melting_point:68 oC
H2o_solubility:0.942 mg/L
Logp:5.162
Isoelectric_point:9.05
Cas_registry_number:84-96-8
Mass_spectrum:http://webbook.nist.gov/cgi/cbook.cgi?Spec=C84968&Index=0&Type=Mass&Large=on
Drug_category:Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05
Indication:Used to prevent and relieve allergic conditions which cause pruritus (itching) and
urticaria (some allergic skin reactions).
Pharmacology:Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in
structure to the phenothiazine antipsychotics, but differing in the
ring-substitution and chain characteristics. Trimeprazine is in the same class of
drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike
the other drugs in this class, trimeprazine is not used clinically as an
anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic
(anti-nausea). Trimeprazine is used principally as an anti-emetic, to prevent motion
sickness or as an anti-histamine in combination with other medications in cough and
cold preparations. Tricyclic antihistamines are also structurally-related to the
tricyclic antidepressants, explaining the antihistaminergic adverse effects of these
two drug classes and also the poor tolerability profile of tricyclic
H1-antihistamines.
Mechanism_of_action:Trimeprazine competes with free histamine for binding at HA-receptor sites. This
antagonizes the effects of histamine on HA-receptors, leading to a reduction of the
negative symptoms brought on by histamine HA-receptor binding.
Organisms_affected:Humans and other mammals

Found: 24 nonactive as graph: single | with analogs [1] << Back 11 12 13 14 15 16 17 18 19 20  Next >> [24]
Species: 4932
Condition: NOP13
Replicates: 2
Raw OD Value: r im 0.6981±0.00784888
Normalized OD Score: sc h 0.9829±0.00123362
Z-Score: -0.8124±0.175495
p-Value: 0.420124
Z-Factor: -6.49905
Fitness Defect: 0.8672
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Lopac
Plate Number and Position:13|A2
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:0.00 Celcius
Date:2005-04-22 YYYY-MM-DD
Plate CH Control (+):0.046925±0.00043
Plate DMSO Control (-):0.6651±0.03004
Plate Z-Factor:0.8516
png
ps
pdf

DBLink | Rows returned: 122 Next >> 
4926 N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine
5574 N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
5887 N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine hydrochloride
28315 N-methyl-3-phenothiazin-10-yl-propan-1-amine
78038 N,N,2,2-tetramethyl-3-phenothiazin-10-yl-propan-1-amine
102719 N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine hydrochloride

internal high similarity DBLink | Rows returned: 1
SPE01500509 1.0000

nonactive | Cluster 17541 | Additional Members: 13 | Rows returned: 122 Next >> 
LOPAC 01155 0.370967741935484
SPE01505498 0.35
Prest888 0.35
Prest536 0.32258064516129
LOPAC 01145 0.32258064516129
SPE01503934 0.32258064516129

Service provided by the Mike Tyers Laboratory