Compound Information | SONAR Target prediction | Name: | Mitoxantrone | Unique Identifier: | LOPAC 01057 | MolClass: | Checkout models in ver1.5 and ver1.0 | Molecular Formula: | C22Cl2H30N4O6 | Molecular Weight: | 487.164 g/mol | X log p: | 6.694 (online calculus) | Lipinksi Failures | 2 | TPSA | 34.14 | Hydrogen Bond Donor Count: | 0 | Hydrogen Bond Acceptors Count: | 10 | Rotatable Bond Count: | 12 | Canonical Smiles: | Cl.Cl.OCCNCCNc1ccc(NCCNCCO)c2c(=O)c3c(O)ccc(O)c3c(=O)c12 | Class: | DNA Metabolism | Action: | Inhibitor |
Species: |
4932 |
Condition: |
SMI1 |
Replicates: |
2 |
Raw OD Value: r im |
0.4254±0.129754 |
Normalized OD Score: sc h |
0.6833±0.185171 |
Z-Score: |
-8.4747±4.3833 |
p-Value: |
0.0000000382302 |
Z-Factor: |
-1.12826 |
Fitness Defect: |
17.0796 |
Bioactivity Statement: |
Active |
Experimental Conditions | | Library: | Lopac | Plate Number and Position: | 10|F10 | Drug Concentration: | 50.00 nM | OD Absorbance: | 600 nm | Robot Temperature: | 27.10 Celcius | Date: | 2005-11-15 YYYY-MM-DD | Plate CH Control (+): | 0.038925±0.02430 | Plate DMSO Control (-): | 0.667825±0.02097 | Plate Z-Factor: | 0.6217 |
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DBLink | Rows returned: 1 | |
4212 |
5,8-dihydroxy-1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione |
internal high similarity DBLink | Rows returned: 0 | |
nonactive | Cluster 14085 | Additional Members: 3 | Rows returned: 1 | |
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