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Compound InformationSONAR Target prediction
Name:

Corticosterone

Unique Identifier:LOPAC 00759
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C21H30O4
Molecular Weight:319.246 g/mol
X log p:0.527  (online calculus)
Lipinksi Failures0
TPSA34.14
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:4
Rotatable Bond Count:2
Canonical Smiles:CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO
Class:Hormone
Selectivity:Glucocorticoid

Found: 24 nonactive as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [24]
Species: 4932
Condition: GAS1
Replicates: 2
Raw OD Value: r im 0.6501±0.032739
Normalized OD Score: sc h 0.9620±0.0324958
Z-Score: -1.8223±1.55961
p-Value: 0.237632
Z-Factor: -2.93247
Fitness Defect: 1.437
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Lopac
Plate Number and Position:3|F11
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:27.30 Celcius
Date:2005-11-17 YYYY-MM-DD
Plate CH Control (+):0.03925±0.00128
Plate DMSO Control (-):0.680275±0.01304
Plate Z-Factor:0.9499
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DBLink | Rows returned: 112 Next >> 
5753 (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17
-dodecahydrocyclopenta[a]phenanthren-3-one
165276 (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dod
ecahydro-1H-cyclopenta[a]phenanthren-3-one
256277 (8S,9S,10R,11R,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17
-dodecahydrocyclopenta[a]phenanthren-3-one
439739 11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phe
nanthren-3-one
439858 (8S,9S,10R,13R,14S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecah
ydrocyclopenta[a]phenanthren-3-one
534502 11-hydroxy-17-(2-hydroxyacetyl)-9,10,13-trimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]ph
enanthren-3-one

internal high similarity DBLink | Rows returned: 6
LOPAC 00951 0.9184
SPE01701060 0.9200
NRB 03831 0.9592
SPE01500380 0.9600
LOPAC 00948 0.9608
SPE00300024 0.9615

nonactive | Cluster 10196 | Additional Members: 12 | Rows returned: 102 Next >> 
Prest672 0.392405063291139
SPE01503273 0.375
SPE01505438 0.352272727272727
SPE01500339 0.2625
LOPAC 00944 0.243589743589744
SPE01500338 0.223684210526316

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