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Compound InformationSONAR Target prediction
Name:

Lithium Chloride

Unique Identifier:LAT006D07
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:CClH5
Molecular Weight:47.4634 g/mol
X log p:0.512  (online calculus)
Lipinksi Failures0
TPSA0
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:0
Rotatable Bond Count:0
Canonical Smiles:[ClH-].C
Generic_name:Cetrorelix
Drug_type:Approved Drug
Pharmgkb_id:PA10255
Drugbank_id:APRD00686
Cas_registry_number:120287-85-6
Drug_category:Infertility Agents; Hormone Antagonists; ATC:H01CC02
Indication:For the inhibition of premature LH surges in women undergoing controlled ovarian
stimulation.
Pharmacology:Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH)
antagonistic activity. GnRH induces the production and release of luteinizing
hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of
the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH
liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation
of the dominant follicle, resumption of oocyte meiosis and subsequently
luteinization as indicated by rising progesterone levels. Cetrorelix competes with
natural GnRH for binding to membrane receptors on pituitary cells and thus controls
the release of LH and FSH in a dose-dependent manner.
Mechanism_of_action:Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent
inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to
membrane receptors on pituitary cells and thus controls the release of LH and FSH in
a dose-dependent manner.
Organisms_affected:Humans and other mammals

Found: 5 nonactive as graph: single | with analogs << Back 1 2 3 4 5 Next >> 
Species: 4932
Condition: pdr22h
Replicates: 2
Raw OD Value: r im 0.6511±0.0374059
Normalized OD Score: sc h 0.9796±0.0463345
Z-Score: -0.6073±1.60368
p-Value: 0.340018
Z-Factor: -7.32147
Fitness Defect: 1.0788
Bioactivity Statement: Nonactive
Experimental Conditions
Library:LATCA
Plate Number and Position:6|D7
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:27.00 Celcius
Date:2007-03-08 YYYY-MM-DD
Plate CH Control (+):0.041575±0.00220
Plate DMSO Control (-):0.6727000000000001±0.01163
Plate Z-Factor:0.9515
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DBLink | Rows returned: 4388[1] << Back 41 42 43 44 45 46 47 48 49 50  Next >> [732]
73976 oxygen(-2) anion; platinum(+4) cation
73977 tin(+4) cation disulfide
73978 selenium(-2) anion; strontium(+2) cation
73979 selenium(-2) anion; zinc
73980 copper selenium(-2) anion
73981 magnesium(+2) cation dihydroxide

internal high similarity DBLink | Rows returned: 0

active | Cluster 1 | Additional Members: 50 | Rows returned: 142 3 Next >> 
LOPAC 00756 0
SPE01503692 0
LAT007G07 0
Prest1291 0
LAT007H07 0
LAT007E08 0

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