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Compound InformationSONAR Target prediction
Name:

Lithium Chloride

Unique Identifier:LAT006D07
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:CClH5
Molecular Weight:47.4634 g/mol
X log p:0.512  (online calculus)
Lipinksi Failures0
TPSA0
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:0
Rotatable Bond Count:0
Canonical Smiles:[ClH-].C
Generic_name:Cetrorelix
Drug_type:Approved Drug
Pharmgkb_id:PA10255
Drugbank_id:APRD00686
Cas_registry_number:120287-85-6
Drug_category:Infertility Agents; Hormone Antagonists; ATC:H01CC02
Indication:For the inhibition of premature LH surges in women undergoing controlled ovarian
stimulation.
Pharmacology:Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH)
antagonistic activity. GnRH induces the production and release of luteinizing
hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of
the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH
liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation
of the dominant follicle, resumption of oocyte meiosis and subsequently
luteinization as indicated by rising progesterone levels. Cetrorelix competes with
natural GnRH for binding to membrane receptors on pituitary cells and thus controls
the release of LH and FSH in a dose-dependent manner.
Mechanism_of_action:Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent
inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to
membrane receptors on pituitary cells and thus controls the release of LH and FSH in
a dose-dependent manner.
Organisms_affected:Humans and other mammals

Found: 5 nonactive as graph: single | with analogs 2 3 4 5 Next >> 
Species: 4932
Condition: pdr18h
Replicates: 2
Raw OD Value: r im 0.6028±0.00183848
Normalized OD Score: sc h 0.9828±0.012765
Z-Score: -0.3600±0.391179
p-Value: 0.728992
Z-Factor: -14.8543
Fitness Defect: 0.3161
Bioactivity Statement: Nonactive
Experimental Conditions
Library:LATCA
Plate Number and Position:6|D7
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:25.40 Celcius
Date:2007-03-08 YYYY-MM-DD
Plate CH Control (+):0.04025±0.00231
Plate DMSO Control (-):0.6212±0.01753
Plate Z-Factor:0.9250
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DBLink | Rows returned: 4388[1] << Back 101 102 103 104 105 106 107 108 109 110  Next >> [732]
159376 thallium(+1) cation sulfide
159380 sodium aluminum(+3) cation tetrafluoride
159384 aluminum(+3) cation; cobalt(+2) cation; oxygen(-2) anion
159385 lead(+2) cation; oxygen(-2) anion
159387 methane; vanadium
159393 cadmium(+2) cation; phosphorus(-3) anion

internal high similarity DBLink | Rows returned: 0

active | Cluster 1 | Additional Members: 50 | Rows returned: 142 3 Next >> 
LOPAC 00756 0
SPE01503692 0
LAT007G07 0
Prest1291 0
LAT007H07 0
LAT007E08 0

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