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Compound InformationSONAR Target prediction
Name:

Progesterone

Unique Identifier:LAT002C06
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C21H30O2
Molecular Weight:284.224 g/mol
X log p:1.893  (online calculus)
Lipinksi Failures0
TPSA34.14
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:2
Rotatable Bond Count:1
Canonical Smiles:CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C
Generic_name:Progesterone
Chemical_iupac_name:17-acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopent
a[a]phenanthren-3-one
Drug_type:Approved Drug
Pharmgkb_id:PA451123
Kegg_compound_id:C00410
Drugbank_id:APRD00700
Melting_point:121 oC
H2o_solubility:8.81 mg/L
Logp:4.036
Cas_registry_number:57-83-0
Mass_spectrum:http://webbook.nist.gov/cgi/cbook.cgi?Spec=C57830&Index=0&Type=Mass&Large=on
Drug_category:Contraceptives; Progestins; ATC:G03AC06; ATC:G03DA02; ATC:G03DA03; ATC:G03DA04;
ATC:L02AB02
Indication:For progesterone supplementation or replacement as part of an Assisted Reproductive
Technology (ART) treatment for infertile women with progesterone deficiency and for
the treatment of secondary amenorrhea. Also used as a female contraceptive.
Pharmacology:Progesterone is a progestin or a synthetic form of the naturally occurring female
sex hormone, progesterone. In a woman-s normal menstrual cycle, an egg matures and
is released from the ovaries (ovulation). The ovary then produces progesterone,
preventing the release of further eggs and priming the lining of the womb for a
possible pregnancy. If pregnancy occurs, progesterone levels in the body remain
high, maintaining the womb lining. If pregnancy does not occur, progesterone levels
in the body fall, resulting in a menstrual period. Progesterone tricks the body
processes into thinking that ovulation has already occurred, by maintaining high
levels of the synthetic progesterone. This prevents the release of eggs from the
ovaries.
Mechanism_of_action:Binds to the progesterone and estrogen receptors. Target cells include the female
reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once
bound to the receptor, progestins like Progesterone will slow the frequency of
release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the
pre-ovulatory LH (luteinizing hormone) surge.
Organisms_affected:Humans and other mammals

Found: 2 active | as graph: single | with analogs << Back 1 2
Species: 4932
Condition: pdr22h
Replicates: 2
Raw OD Value: r im 0.6033±0.000919239
Normalized OD Score: sc h 0.8758±0.01143
Z-Score: -4.8363±1.14083
p-Value: 0.0000279436
Z-Factor: 0.511174
Fitness Defect: 10.4853
Bioactivity Statement: Active
Experimental Conditions
Library:LATCA
Plate Number and Position:2|C6
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:26.90 Celcius
Date:2007-03-08 YYYY-MM-DD
Plate CH Control (+):0.040625±0.00276
Plate DMSO Control (-):0.6738±0.00616
Plate Z-Factor:0.9618
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DBLink | Rows returned: 718[1] << Back 61 62 63 64 65 66 67 68 69 70  Next >> [120]
7166653 (2R)-2-[(8S,9R,10S,13R,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta
[a]phenanthren-17-yl]propanal
7166654 (2S)-2-[(8S,9R,10S,13R,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta
[a]phenanthren-17-yl]propanal
7213685 (8S,9R,10S,13R,14R)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-di
one
7213686 (8S,9S,10S,13R,14R)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-di
one
7543587 (8S,9R,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodec
ahydrocyclopenta[a]phenanthren-3-one
7543607 (8S,9R,10R,13R,14S,17S)-10,13-dimethyl-17-[(2S)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodec
ahydrocyclopenta[a]phenanthren-3-one

internal high similarity DBLink | Rows returned: 112 Next >> 
LOPAC 00696 1.0000
SPE01500508 1.0000
SPE00270067 1.0000
SB 01791 1.0000
SB 01194 1.0000
Prest411 1.0000

active | Cluster 2094 | Additional Members: 20 | Rows returned: 6
SPE00300034 0.375
SPE00307023 0.348484848484849
SPE00300029 0.285714285714286
SPE01500508 0
LAT005F10 0
LOPAC 01120 0

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